N,N'-bis-(2-amino-ethyl)-N,N'-dimethyl-propane-1,3-diamine → 3-chloro-6-{2-[(3-{[2-(3-chloro-7-oxo-7H-5,10-diaza-benzo[c]fluoren-6-ylamino)-ethyl]-methyl-amino}-propyl)-methyl-amino]-ethylamino}-5,10-diaza-benzo[c]fluoren-7-one

HRID 496745Notes

Reaction equation

HRID 496745 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:17]3[C:16]4[CH:15]=[N:14][CH:13]=[CH:12][C:11]=4[C:10](=[O:18])[C:9]=3[C:8](OS(C3C=CC(C)=CC=3)(=O)=O)=[N:7][C:6]=2[CH:30]=1.[NH2:31][CH2:32][CH2:33][N:34]([CH3:43])[CH2:35][CH2:36][CH2:37][N:38]([CH2:40][CH2:41][NH2:42])[CH3:39]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:17]3[C:16]4[CH:15]=[N:14][CH:13]=[CH:12][C:11]=4[C:10](=[O:18])[C:9]=3[C:8]([NH:42][CH2:41][CH2:40][N:38]([CH2:37][CH2:36][CH2:35][N:34]([CH2:33][CH2:32][NH:31][C:8]3[C:9]4[C:10](=[O:18])[C:11]5[CH:12]=[CH:13][N:14]=[CH:15][C:16]=5[C:17]=4[C:5]4[CH:4]=[CH:3][C:2]([Cl:1])=[CH:30][C:6]=4[N:7]=3)[CH3:43])[CH3:39])=[N:7][C:6]=2[CH:30]=1

Participants

3

Reactant 2

HCID 10607670N,N'-bis-(2-amino-ethyl)-N,N'-dimethyl-propane-1,3-diamineHCID 20829787toluene-4-sulfonic acid 3-chloro-7-oxo-7H-5,10-diaza-benzo[c]fluoren-6-yl ester

Product 1

HCID 104174143-chloro-6-{2-[(3-{[2-(3-chloro-7-oxo-7H-5,10-diaza-benzo[c]fluoren-6-ylamino)-ethyl]-methyl-amino}-propyl)-methyl-amino]-ethylamino}-5,10-diaza-benzo[c]fluoren-7-one

Procedure

In a similar manner to Example 4, this compound was obtained starting from toluene-4-sulfonic acid 3-chloro-7-oxo-7H-5,10-diaza-benzo[c]fluoren-6-yl ester (the compound of Reference Example 7c-1) and N,N′-bis-(2-amino-ethyl)-N,N′-dimethyl-propane-1,3-diamine. The desired product was obtained as a reddish powder.

Workup

  1. customIn a similar manner to Example 4, this compound was obtained

Sources & evidence

ORD record
ord-0f0fe11fc3ca4bef8447589fff63755d
Source dataset
uspto-grants-2005_09
Patent number
US06946472B2

Reaction notes

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