N,N'-bis-(2-amino-ethyl)-N,N'-dimethyl-propane-1,3-diamine → 11-chloro-6-{2-[(3-{[2-(11-chloro-3-methoxy-4-methyl-7-oxo-7H-5,10-diaza-benzo[c]fluoren-6-ylamino)-ethyl]-methyl-amino}-propyl)-methylamino]-ethylamino}-3-methoxy-4-methyl-5,10-diaza-benzo[c]fluoren-7-one

HRID 496746Notes

Reaction equation

HRID 496746 reaction equation
[Cl:1][C:2]1[C:3]2[C:4]3[C:5]4[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[C:27]([CH3:33])[C:6]=4[N:7]=[C:8](OS(C4C=CC(C)=CC=4)(=O)=O)[C:9]=3[C:10](=[O:15])[C:11]=2[CH:12]=[CH:13][N:14]=1.[NH2:34][CH2:35][CH2:36][N:37]([CH3:46])[CH2:38][CH2:39][CH2:40][N:41]([CH2:43][CH2:44][NH2:45])[CH3:42]>>[Cl:1][C:2]1[C:3]2[C:4]3[C:5]4[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[C:27]([CH3:33])[C:6]=4[N:7]=[C:8]([NH:45][CH2:44][CH2:43][N:41]([CH2:40][CH2:39][CH2:38][N:37]([CH2:36][CH2:35][NH:34][C:8]4[C:9]5[C:10](=[O:15])[C:11]6[CH:12]=[CH:13][N:14]=[C:2]([Cl:1])[C:3]=6[C:4]=5[C:5]5[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[C:27]([CH3:33])[C:6]=5[N:7]=4)[CH3:46])[CH3:42])[C:9]=3[C:10](=[O:15])[C:11]=2[CH:12]=[CH:13][N:14]=1

Participants

3

Reactant 2

HCID 10607670N,N'-bis-(2-amino-ethyl)-N,N'-dimethyl-propane-1,3-diamineHCID 20829788toluene-4-sulfonic acid 11-chloro-3-methoxy-4-methyl-7-oxo-7H-5,10-diaza-benzo[c]fluoren-6-yl ester

Product 1

HCID 1044038511-chloro-6-{2-[(3-{[2-(11-chloro-3-methoxy-4-methyl-7-oxo-7H-5,10-diaza-benzo[c]fluoren-6-ylamino)-ethyl]-methyl-amino}-propyl)-methylamino]-ethylamino}-3-methoxy-4-methyl-5,10-diaza-benzo[c]fluoren-7-one

Procedure

In a similar manner to Example 4, this compound was obtained starting from toluene-4-sulfonic acid 11-chloro-3-methoxy-4-methyl-7-oxo-7H-5,10-diaza-benzo[c]fluoren-6-yl ester (the compound of Reference Example 5) and N,N′-bis-(2-amino-ethyl)-N,N′-dimethyl-propane-1,3-diamine. The desired product was obtained as a reddish powder.

Workup

  1. customIn a similar manner to Example 4, this compound was obtained

Sources & evidence

ORD record
ord-beb4baff74c5490692df59351259275c
Source dataset
uspto-grants-2005_09
Patent number
US06946472B2

Reaction notes

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