HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 496788Generated: October 30, 2026
Sodium Hydroxide → [3-(5-Methyl[1,2,4]oxadiazol-3-yl)phenoxy]-2-phenylacetic acid
https://huagongshe.com/reaction/496788
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl [3-(5-methyl[1,2,4]oxadiazol-3-yl)phenoxy]-2-phenylacetate | HCID 12042529 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | [3-(5-Methyl[1,2,4]oxadiazol-3-yl)phenoxy]-2-phenylacetic acid | HCID 12042530 | — |
Reaction Steps
A solution of 1.77 g (5.46 mmol) of methyl [3-(5-methyl[1,2,4]oxadiazol-3-yl)phenoxy]-2-phenylacetate in 15 ml of methanol is treated with 10 ml of 1 N aqueous sodium hydroxide solution and heated at 80° C. for 3 hours. The reaction mixture is concentrated and the residue is treated with 1 N hydrochloric acid. It is extracted with ethyl acetate and the organic phase is evaporated. A colourless solid is obtained; FAB 311
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06946489B2 |
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| Source dataset | uspto-grants-2005_09 |
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| ORD ID | ord-be975549409e4620a84c8a839aab11e0 |
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| Source note | uspto-grants-2005_09 |
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