Ammonia → HCID 15551924, compound

HRID 496792Notes

Reaction equation

HRID 496792 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH:16]=[CH:15][C:14]([C:17]#[N:18])=[CH:13][CH:12]=1)(=[O:4])=[O:3].N.C1COCC1>CO.[Ni]>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH:12]=[CH:13][C:14]([CH2:17][NH2:18])=[CH:15][CH:16]=1)(=[O:3])=[O:4]

Participants

6

Reactant 3

HCID 222AmmoniaHCID 8028TetrahydrofuranHCID 22323113HCID 22323113, compound

Product 1

HCID 15551924HCID 15551924, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

A solution of 1.0 g (3.9 mmol) of 2′-methanesulfonylbiphenyl-4-carbonitrile in a mixture of 10 ml of methanol saturated with ammonia and 3 ml of THF is treated with 400 mg of Raney nickel and hydrogenated at room temperature and normal pressure. The catalyst is filtered off and the filtrate is evaporated. A colourless solid is obtained; FAB 262

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe filtrate is evaporated
  3. customA colourless solid is obtained

Sources & evidence

ORD record
ord-dd2465d68f5e43029280eb64999ccb17
Source dataset
uspto-grants-2005_09
Patent number
US06946489B2

Reaction notes

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