Cesium carbonate → HCID 22323115, compound

HRID 496795Notes

Reaction equation

HRID 496795 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]#[N:6].Br[CH:11]([CH2:17][CH2:18][CH3:19])[C:12]([O:14][CH2:15][CH3:16])=[O:13].C(=O)([O-])[O-].[Cs+].[Cs+]>C(#N)C>[C:5]([C:4]1[CH:3]=[C:2]([CH:9]=[CH:8][CH:7]=1)[O:1][CH:11]([CH2:17][CH2:18][CH3:19])[C:12]([O:14][CH2:15][CH3:16])=[O:13])#[N:6]

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 133943-CyanophenolHCID 79071Ethyl 2-bromovalerate

Product 1

HCID 22323115HCID 22323115, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 5.0 g (42 mmol) of 3-hydroxybenzonitrile and 8.78 g (42.0 mmol) of ethyl 2-bromovalerate in 80 ml of acetonitrile is treated with 13.7 g (42.0 mmol) of caesium carbonate and stirred at room temperature for 18 hours. The reaction mixture is filtered off and the filtrate evaporated. A colourless oil is obtained; FAB 248

Workup

  1. filtrationThe reaction mixture is filtered off
  2. customthe filtrate evaporated
  3. customA colourless oil is obtained

Sources & evidence

ORD record
ord-f11b29b50631449ba176e1175d25ae60
Source dataset
uspto-grants-2005_09
Patent number
US06946489B2

Reaction notes

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