Lithium Hydroxide → HCID 22323098, compound

HRID 496796Notes

Reaction equation

HRID 496796 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:16]=[CH:17][CH:18]=1)[O:6][CH:7]([CH2:13][CH2:14][CH3:15])[C:8]([O:10]CC)=[O:9])#[N:2].[OH-].[Li+]>CO.O>[C:1]([C:3]1[CH:4]=[C:5]([CH:16]=[CH:17][CH:18]=1)[O:6][CH:7]([CH2:13][CH2:14][CH3:15])[C:8]([OH:10])=[O:9])#[N:2]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 22323115HCID 22323115, compound

Product 1

HCID 22323098HCID 22323098, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of 9.00 g (36.5 mmol) of ethyl 2-(3-cyanophenoxy)pentanoate in 10 ml of methanol is treated with a solution of 1.29 g (54.0 mmol) of lithium hydroxide in 10 ml of water and the mixture is stirred at room temperature for 18 hours. The reaction mixture is concentrated in vacuo, extracted with ethyl acetate, and the aqueous phase is acidified and extracted with ethyl acetate. The organic phase is dried over sodium sulfate and evaporated. A colourless solid is obtained; FAB 220

Workup

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. extractionextracted with ethyl acetate
  3. extractionextracted with ethyl acetate
  4. dry with materialThe organic phase is dried over sodium sulfate
  5. customevaporated
  6. customA colourless solid is obtained

Sources & evidence

ORD record
ord-75939cdf561c48a3a3de19daad7c6888
Source dataset
uspto-grants-2005_09
Patent number
US06946489B2

Reaction notes

Loading…