Triethylamine → HCID 178450152, compound

HRID 496797Notes

Reaction equation

HRID 496797 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18](=[O:32])[CH:19]([O:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([C:30]#[N:31])[CH:25]=2)[CH2:20][CH2:21][CH3:22])=[CH:13][CH:12]=1)(=[O:4])=[O:3].Cl.[Cl-].[OH:35][NH3+:36].C(N(CC)CC)C>CO.O>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH:12]=[CH:13][C:14]([NH:17][C:18](=[O:32])[CH:19]([O:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([C:30](=[NH:31])[NH:36][OH:35])[CH:25]=2)[CH2:20][CH2:21][CH3:22])=[CH:15][CH:16]=1)(=[O:3])=[O:4]

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 20870619HCID 20870619, compoundHCID 22323132HCID 22323132, compound

Product 1

HCID 178450152HCID 178450152, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

A solution of 1.40 g (3.12 mmol) of 2-(3-cyanophenoxy)pentanoic acid (2′-methanesulfonylbiphenyl-4-yl)amide in 50 ml of methanol is treated with 695 mg (10.0 mmol) of hydroxylammonium chloride hydrochloride and 1.01 g (10.0 mmol) of triethylamine and stirred at 60° C. for 18 hours. It is allowed to cool, the solvent is stripped off, the residue is taken up in water and the resulting precipitate is filtered off. A colourless solid is obtained; FAB 482

Workup

  1. temperatureto cool
  2. filtrationthe resulting precipitate is filtered off
  3. customA colourless solid is obtained

Sources & evidence

ORD record
ord-b66eb58ed5e94213a2ea45db6c08b365
Source dataset
uspto-grants-2005_09
Patent number
US06946489B2

Reaction notes

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