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HRID496801

反应详情

EQUATION

反应方程式

HRID 496801 的结构方程式

REACTANTS

反应物

3
结构：COc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314
HCID5284569

Hydrocodone

C18H21NO3

结构：COC1=CC=C2[C@H]3Cc4ccc(OC)c5c4[C@@]2(CCN3C)[C@H]1O5
HCID5324289

Thebaine

C19H21NO3

结构：COc1ccc2c3c1O[C@H]1C(=O)C=C[C@H]4[C@@H](C2)N(C)CC[C@]314
HCID5459910

Codeinone

C18H19NO3

PRODUCTS

生成物

3
结构：COc1ccc2c3c1O[C@H]1[C@@H](O)C=C[C@H]4[C@@H](C2)N(C)CC[C@@]341
HCID5284371

Codeine

C18H21NO3

结构：COC1=CC=C2[C@H]3Cc4ccc(OC)c5c4[C@@]2(CCN3C)[C@H]1O5
HCID5324289

Thebaine

C19H21NO3

结构：COc1ccc2c3c1O[C@H]1C(=O)C=C[C@H]4[C@@H](C2)N(C)CC[C@]314
HCID5459910

Codeinone

C18H19NO3

PROCEDURE

实验过程

Hydrocodone has been prepared by reduction of codeinone (Arch. Pharm (1920), 258, 295; J. Am Chem. Soc (1950), 72, 3247, U.S. Pat. No. 5,571,685) or thebaine (DE Pat. No. 441,613). However, since codeinone is obtained by oxidation of codeine in low to moderate yields, and thebaine is a relatively scarce alkaloid, these methods have little practical value.