HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrocodone → Codeine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrocodone | HCID 5284569 | — |
| Reactant | Thebaine | HCID 5324289 | — |
| Reactant | Codeinone | HCID 5459910 | — |
| Product | Codeine | HCID 5284371 | — |
| Product | Thebaine | HCID 5324289 | — |
| Product | Codeinone | HCID 5459910 | — |
Reaction Steps
Hydrocodone has been prepared by reduction of codeinone (Arch. Pharm (1920), 258, 295; J. Am Chem. Soc (1950), 72, 3247, U.S. Pat. No. 5,571,685) or thebaine (DE Pat. No. 441,613). However, since codeinone is obtained by oxidation of codeine in low to moderate yields, and thebaine is a relatively scarce alkaloid, these methods have little practical value.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06946556B1 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-c46228bdbd2a46d990394e87ee0a0f24 |
| Source note | uspto-grants-2005_09 |