反应详情

2,5-dibromo pyridine (5 g) was mixed with sodium thiomethoxide (1.4 g) and dissolved in dimethylformamide (30 ml) and then, refluxed for 5 hours. After completing the reaction, water was added to dilute and extracted with ethylacetate to separate an organic layer. The separated organic layer was dried with anhydrous magnesium sulfate, distilled under reduced pressure, and separated by performing a silica gel attributed chromatography (ethylacetate:normal hexane=1:15) As a result, 5-bromo-2-methylsulfanyl pyridine (3.47 g, yield: 80%) was obtained as an oil phase.

1. temperaturerefluxed for 5 hours
2. additionwas added
3. additionto dilute
4. extractionextracted with ethylacetate
5. customto separate an organic layer
6. dry with materialThe separated organic layer was dried with anhydrous magnesium sulfate
7. distillationdistilled under reduced pressure
8. customseparated