Cyclohexanecarboxaldehyde → 3-Cyclohexyl-2-dimethoxymethylacrylonitrile

HRID 496820Notes

Reaction equation

HRID 496820 reaction equation
[CH:1]1([CH:7]=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:9][O:10][CH:11]([O:15][CH3:16])[CH2:12][C:13]#[N:14].C[O-].[Na+]>CO>[CH3:9][O:10][CH:11]([O:15][CH3:16])[C:12](=[CH:7][CH:1]1[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1)[C:13]#[N:14]

Participants

5

Reactant 3

HCID 16275CyclohexanecarboxaldehydeHCID 937313,3-DimethoxypropiononitrileHCID 10942334Sodium Methoxide

Product 1

HCID 543234033-Cyclohexyl-2-dimethoxymethylacrylonitrile

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Cyclohexanecarboxaldehyde (50.0 g, 0.45 mol) was added to a stirred mixture of 3,3-dimethoxypropionitrile (11.5, g, 1.0 mol) and sodium methoxide (54.0 g, 1.0 mol) in methanol over a period of 15 minutes. The mixture was then stirred overnight at room temperature.

Sources & evidence

ORD record
ord-0429e80645bb4e15bfebdeef62abd246
Source dataset
uspto-grants-2005_09
Patent number
US06946554B2

Reaction notes

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