反应详情

温度

5 °C

A solution (94.1 kg including citalopram 51.8 kg) of citalopram in acetone produced in Example 30 was added to acetone (163.4 kg) and hydrogen bromide (13.2 kg) was blown in over 3 hr at 25-35° C. After aging for 3 hr, the mixture was cooled to about 5° C. and aged at 0-5° C. for three more hours. The crystals were collected by filtration and washed with acetone (40.9 kg) cooled to 0-5° C. The crystals were dried under reduced pressure at 30-50° C. to give citalopram hydrobromide (54.9 kg, yield 83.7%).

1. customwas blown in over 3 hr at 25-35° C
2. customaged at 0-5° C. for three more hours
3. filtrationThe crystals were collected by filtration
4. washwashed with acetone (40.9 kg)
5. temperaturecooled to 0-5° C
6. customThe crystals were dried under reduced pressure at 30-50° C.