Trifluoroacetic acid → [4-(2-Aminoethyl)-1-piperazinyl](3,4-dichlorophenyl)methanone trifluoroacetate

HRID 496880Notes

Reaction equation

HRID 496880 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:23]=[CH:24][C:25]=1[Cl:26])[C:5]([N:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][NH:15]C(=O)OC(C)(C)C)[CH2:9][CH2:8]1)=[O:6].[F:27][C:28]([F:33])([F:32])[C:29]([OH:31])=[O:30]>ClCCl>[F:27][C:28]([F:33])([F:32])[C:29]([OH:31])=[O:30].[NH2:15][CH2:14][CH2:13][N:10]1[CH2:11][CH2:12][N:7]([C:5]([C:4]2[CH:23]=[CH:24][C:25]([Cl:26])=[C:2]([Cl:1])[CH:3]=2)=[O:6])[CH2:8][CH2:9]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22322333tert-Butyl 2-[4-(3,4-dichlorobenzoyl)-1-piperazinyl]ethylcarbamate

Product 1

HCID 22322358[4-(2-Aminoethyl)-1-piperazinyl](3,4-dichlorophenyl)methanone trifluoroacetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product from step (ii) above (3.3 g) was dissolved in dichloromethane (50 ml) and trifluoroacetic acid (10 ml) added. After 16 hours at room temperature the solvent was removed to give the sub-titled product as an oil (5.9 g).

Workup

  1. customAfter 16 hours at room temperature the solvent was removed

Sources & evidence

ORD record
ord-1591b1d4ccf24aebb60c8cb4113c009f
Source dataset
uspto-grants-2005_09
Patent number
US06946478B2

Reaction notes

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