反应详情

The product of step (i) (1.57 g) was dissolved in dichloromethane (14 ml) and trifluoroacetic acid (4 ml) added. After 2 hours at room temperature the solvent was removed, ethyl acetate and 2N aqueous NaOH solution were added to give pH 8.0. The organic phase was separated and concentrated to give the sub-titled product as an oil (1.24 g) which was used in the next step without further purification.

1. customAfter 2 hours at room temperature the solvent was removed
2. additionethyl acetate and 2N aqueous NaOH solution were added
3. customto give pH 8.0
4. customThe organic phase was separated
5. concentrationconcentrated