Trifluoroacetic acid → HCID 22322416, compound

HRID 496886Notes

Reaction equation

HRID 496886 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][C:21]=1[Cl:22])[NH:5][CH:6]1[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]1.[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26]>ClCCl>[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26].[Cl:1][C:2]1[CH:3]=[C:4]([NH:5][CH:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH:19]=[CH:20][C:21]=1[Cl:22]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 223224131-Boc-4-[(3,4-dichlorophenyl)amino]-piperidine

Product 1

HCID 22322416HCID 22322416, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product of step (i) above (6.5 g) was dissolved in dichloromethane (75 ml) and trifluoroacetic acid (25 ml) added. After 72 hours at room temperature the solution was evaporated and the residue triturated under ether to give the sub-titled product as a solid (6.3 g).

Workup

  1. customAfter 72 hours at room temperature the solution was evaporated
  2. customthe residue triturated under ether

Sources & evidence

ORD record
ord-a777fbf1c99f4d82843e2bbe2bdad68e
Source dataset
uspto-grants-2005_09
Patent number
US06946478B2

Reaction notes

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