Trifluoroacetic acid → HCID 69779002, compound

HRID 496888Notes

Reaction equation

HRID 496888 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:22]=[CH:23][C:24]=1[Cl:25])[NH:5][CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][NH:14]C(=O)OC(C)(C)C)[CH2:8][CH2:7]1.FC(F)(F)C(O)=O>ClCCl>[NH2:14][CH2:13][CH2:12][N:9]1[CH2:10][CH2:11][CH:6]([NH:5][C:4]2[CH:22]=[CH:23][C:24]([Cl:25])=[C:2]([Cl:1])[CH:3]=2)[CH2:7][CH2:8]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22322328HCID 22322328, compound

Product 1

HCID 69779002HCID 69779002, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product from step (iii) above (1.2 g) was dissolved in dichloromethane (30 ml) and trifluoroacetic acid (10 ml) added. After 72 hours at room temperature the reaction mixture was evaporated and residue triturated under ether to give the sub-titled product as a solid (1.6 g).

Workup

  1. customAfter 72 hours at room temperature the reaction mixture was evaporated
  2. customresidue triturated under ether

Sources & evidence

ORD record
ord-0be3034b8b67408a9b26b20632942741
Source dataset
uspto-grants-2005_09
Patent number
US06946478B2

Reaction notes

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