反应详情

A solution of the product from Example 1 step (ii) (2.0 g), 2-(3-bromopropyl)-1H-isoindole-1,3(2H)-dione (1.61 g) and triethylamine (2.5 ml) in dichloromethane (40 ml) was heated under reflux for 48 h. The reaction mixture was partitioned between ethyl acetate/water, the organic layer dried and evaporated under reduced pressure. Purification was by chromatography eluting with 4% methanol/dichloromethane. Yield 0.839 g

1. temperatureunder reflux for 48 h
2. customThe reaction mixture was partitioned between ethyl acetate/water
3. customthe organic layer dried
4. customevaporated under reduced pressure
5. customPurification
6. washeluting with 4% methanol/dichloromethane