Ammonium Hydroxide → HCID 178508315, compound

HRID 496983Notes

Reaction equation

HRID 496983 reaction equation
[OH:1][CH2:2][CH:3]1[CH:7]([OH:8])[CH2:6][CH:5]([C:9]2[N:14]=[C:13]3[NH:15][N:16]=[C:17]([I:18])[C:12]3=[C:11](C)[N:10]=2)[O:4]1.[OH-].[NH4+:21]>>[NH2:21][C:11]1[N:10]=[C:9]([CH:5]2[O:4][CH:3]([CH2:2][OH:1])[CH:7]([OH:8])[CH2:6]2)[N:14]=[C:13]2[NH:15][N:16]=[C:17]([I:18])[C:12]=12

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 178432601HCID 178432601, compound

Product 1

HCID 178508315HCID 178508315, compound

Procedure

Compound 8 (6.8 g, 17.35 mmol) was stirred in 200 mL of concentrated ammonium hydroxide (sealed container) at room temperature for 36 h. The mixture was evaporated and the residue was precipitated from acetonitrile-ether. The solid was filtered and dried: 5.36 g (82%) yield. NMR and spectral data on this compound is identical to

Workup

  1. customThe mixture was evaporated
  2. customthe residue was precipitated from acetonitrile-ether
  3. filtrationThe solid was filtered
  4. customdried
  5. custom5.36 g (82%) yield

Sources & evidence

ORD record
ord-aca91e98c0e8454e982aa83aa7ddfc20
Source dataset
uspto-grants-2005_09
Patent number
US06949367B1

Reaction notes

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