(1-Methyl-1H-1,2,4-triazol-3-yl)methanol → 6-(2-Methyl-1,2,4-triazol-5-yl)methyloxy-3-(isoxazol-3-yl)imidazo[5,1-a]phthalazine

HRID 497038Notes

Reaction equation

HRID 497038 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]2=[CH:12][N:13]=[C:14]([C:15]3[CH:19]=[CH:18][O:17][N:16]=3)[N:4]2[N:3]=1.[CH3:20][N:21]1[CH:25]=[N:24][C:23]([CH2:26][OH:27])=[N:22]1>>[CH3:20][N:21]1[CH:25]=[N:24][C:23]([CH2:26][O:27][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]3=[CH:12][N:13]=[C:14]([C:15]4[CH:19]=[CH:18][O:17][N:16]=4)[N:4]3[N:3]=2)=[N:22]1

Participants

3

Reactant 2

HCID 10351670(1-Methyl-1H-1,2,4-triazol-3-yl)methanolHCID 223185166-Chloro-3-(isoxazol-3-yl)-imidazo[5,1-a]phthalazine

Product 1

HCID 223185196-(2-Methyl-1,2,4-triazol-5-yl)methyloxy-3-(isoxazol-3-yl)imidazo[5,1-a]phthalazine

Procedure

The title compound was prepared from 6-chloro-3-(isoxazol-3-yl)-imidazo[5,1-a]phthalazine (Part b) and (2-methyl-1,2,4-triazol-5-yl)methanol as described in Example 1, Part c. 1H NMR (360 MHz, CDCl3) δ 3.96 (s, 3H), 5.7 (s, 2H), 7.40 (s, 1H), 7.52 (t, J=8 Hz, 1H), 7.76 (t, J=8 Hz, 1H), 7.89 (s, 1H), 8.0 (d, J=8 Hz, 1H), 8.17 (d, J=8 Hz, 1H), 8.56 (s, 1H). MS (ES+) m/e 348 [MH]+.

Sources & evidence

ORD record
ord-8c9dac29bed34dd1b24e187b7f8178b9
Source dataset
uspto-grants-2005_09
Patent number
US06949549B2

Reaction notes

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