Ethanolamine → HCID 22318628, compound

HRID 497056Notes

Reaction equation

HRID 497056 reaction equation
[Cl:1][C:2]1[C:3]([O:17][CH2:18][CH2:19][CH2:20][O:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][N:23]=2)=[C:4]([CH:8]=[C:9]([O:11][CH2:12][CH:13]=[C:14]([Cl:16])[Cl:15])[CH:10]=1)[C:5](O)=[O:6].C(N1C=CN=C1)(N1C=CN=C1)=O.[NH2:44][CH2:45][CH2:46][OH:47]>C1(C)C=CC=CC=1>[OH:47][CH2:46][CH2:45][NH:44][C:5](=[O:6])[C:4]1[CH:8]=[C:9]([O:11][CH2:12][CH:13]=[C:14]([Cl:16])[Cl:15])[CH:10]=[C:2]([Cl:1])[C:3]=1[O:17][CH2:18][CH2:19][CH2:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:29])[F:30])=[CH:24][N:23]=1

Participants

5

Reactant 3

HCID 700EthanolamineHCID 682631,1'-CarbonyldiimidazoleHCID 22318624HCID 22318624, compound

Product 1

HCID 22318628HCID 22318628, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

0.2 g of 3-chloro-5-(3,3-dichloroprop-2-enyloxy)-2-[3-(5-trifluoromethylpyrid-2-yloxy)-propyloxy]benzoic acid and 0.065 g of carbonyldiimidazole were allowed to react at room temperature in 4 ml of anhydrous toluene for 1.5 hours. 0.027 g of 2-amino-ethanol was then added, and the mixture was stirred at room temperature for another hour. The reaction mixture was concentrated under reduced pressure and purified by column chromatography. Yield: 0.159 g (73%)

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. custompurified by column chromatography

Sources & evidence

ORD record
ord-9287c58c8247450bbc38f8f26d8ac2c2
Source dataset
uspto-grants-2005_09
Patent number
US06949551B2

Reaction notes

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