反应详情

A solution of (E/Z) ethyl 3-(6-acetylamino-pyrid-3yl)-but-2-enoate (27.3 g, Reference Example 22) in ethanol (500 mL) was hydrogenated (3bar hydrogen pressure) at 50° C. using 10% palladium on charcoal (1.0 g) as catalyst. After 48 h, the mixture was degassed, filtered through a pad of diatomaceous earth and the pad rinsed through with ethanol. The filtrate was evaporated to give the title compound as an oil.

1. customat 50° C.
2. customthe mixture was degassed
3. filtrationfiltered through a pad of diatomaceous earth
4. washthe pad rinsed through with ethanol
5. customThe filtrate was evaporated