Ethyl 3-(6-acetylamino-pyrid-3-yl)-but-2-enoate → (RS) ethyl 3-(6-acetylamino-pyrid-3-yl)-butanoate

Participants

Reaction Steps

A solution of (E/Z) ethyl 3-(6-acetylamino-pyrid-3yl)-but-2-enoate (27.3 g, Reference Example 22) in ethanol (500 mL) was hydrogenated (3bar hydrogen pressure) at 50° C. using 10% palladium on charcoal (1.0 g) as catalyst. After 48 h, the mixture was degassed, filtered through a pad of diatomaceous earth and the pad rinsed through with ethanol. The filtrate was evaporated to give the title compound as an oil.

Provenance & Evidence