反应详情

A mixture of 1-[3-fluoro-4-(methylsulfonyl)phenyl]pentane-1,4-dione (2.8 g, 10.3 mmol), 4-bromoaniline (2.12 g, 12.3 mmol), and p-toluenesulfonic acid (150 mg) in toluene (250 mL) was heated at reflux temperature using Dean-Stark apparatus. After cooling down, volatiles were removed by evaporation. The residue was purified by flash chromatography on silica gel eluting with ethyl acetate/hexane (1/5) to give the subtitle compound (4 g, 95% yield).

1. temperaturewas heated
2. temperatureat reflux temperature
3. temperatureAfter cooling down
4. customvolatiles were removed by evaporation
5. customThe residue was purified by flash chromatography on silica gel eluting with ethyl acetate/hexane (1/5)