反应详情

温度

60 °C

A solution of (RS) methyl 3-{5-[2-(3-hydroxy-4-nitrophenyl)-acetylamino]-pyridin-2-yl}-butanoate (2.0 g, Reference Example 25) in ethanol (80 mL), at 60° C., was treated with ammonium formate (4.0 g) and 10% palladium on charcoal (0.5 g). After stirring at 60° C. for 1 hour the reaction mixture was cooled and then filtered. The filtrate was evaporated and the residue was dissolved in ethyl acetate. This solution was washed twice with water, then dried over magnesium sulphate and then evaporated to give the title compound (1.37 g) as an oil.

1. temperaturewas cooled
2. filtrationfiltered
3. customThe filtrate was evaporated
4. dissolutionthe residue was dissolved in ethyl acetate
5. washThis solution was washed twice with water
6. dry with materialdried over magnesium sulphate
7. customevaporated