Hydrochloric Acid → HCID 22316755, compound

Participants

Reaction Steps

To a stirred solution of Ethyl 5-[4-(2-furyl)phenyl]-1-[4-(methylsulfonyl)phenyl]-1H-pyrazole-3-carboxylate (prepared according to the procedure of Example 63, step 1) (0.1 g) in ethanol (5 mL)-THF (3 mL) was added 2N-Sodium hydroxied solution in water (1 mL) and the mixture was heated at reflux temperature for 1.5 hours. After cooling, 2N—HCl solution (2 mL) and water (20 mL) were added to the mixture. The whole was extracted with CH2Cl2 (50 mL×2), the organic layer was washed with brine, dried over MgSO4, and concentrated in vacuo. The resulting solid was recrystallized with isopropanol-water to give the title compound (0.08 g).

Provenance & Evidence