Hydrochloric Acid → HCID 22316755, compound

HRID 497205Notes

Reaction equation

HRID 497205 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:16]([C:17]3[CH:22]=[CH:21][C:20]([S:23]([CH3:26])(=[O:25])=[O:24])=[CH:19][CH:18]=3)[N:15]=[C:14]([C:27]([O:29]CC)=[O:28])[CH:13]=2)=[CH:8][CH:7]=1.C1COCC1.[Na].Cl>C(O)C.O>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:7]=[CH:8][C:9]([C:12]2[N:16]([C:17]3[CH:22]=[CH:21][C:20]([S:23]([CH3:26])(=[O:24])=[O:25])=[CH:19][CH:18]=3)[N:15]=[C:14]([C:27]([OH:29])=[O:28])[CH:13]=2)=[CH:10][CH:11]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 5360545SodiumHCID 22316679HCID 22316679, compound

Product 1

HCID 22316755HCID 22316755, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent2×

Procedure

To a stirred solution of Ethyl 5-[4-(2-furyl)phenyl]-1-[4-(methylsulfonyl)phenyl]-1H-pyrazole-3-carboxylate (prepared according to the procedure of Example 63, step 1) (0.1 g) in ethanol (5 mL)-THF (3 mL) was added 2N-Sodium hydroxied solution in water (1 mL) and the mixture was heated at reflux temperature for 1.5 hours. After cooling, 2N—HCl solution (2 mL) and water (20 mL) were added to the mixture. The whole was extracted with CH2Cl2 (50 mL×2), the organic layer was washed with brine, dried over MgSO4, and concentrated in vacuo. The resulting solid was recrystallized with isopropanol-water to give the title compound (0.08 g).

Workup

  1. temperaturethe mixture was heated
  2. temperatureat reflux temperature for 1.5 hours
  3. temperatureAfter cooling
  4. extractionThe whole was extracted with CH2Cl2 (50 mL×2)
  5. washthe organic layer was washed with brine
  6. dry with materialdried over MgSO4
  7. concentrationconcentrated in vacuo
  8. customThe resulting solid was recrystallized with isopropanol-water

Sources & evidence

ORD record
ord-59d283f984c44a418a37ecaf39ef05fb
Source dataset
uspto-grants-2005_09
Patent number
US06949536B2

Reaction notes

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