反应详情

To a stirred solution of 2-[4-(5-oxazolyl)phenyl]-2-methyl-1,3-dioxolane (711 mg, 3.08 mmol) in acetone (18 ml) and water (2.8 ml) was added pyridinium p-toluenesulfonate (116 mg, 0.46 mmol), and the mixture was heated at reflux temperature for 8 hours. The mixture was cooled down to room temperature, and concentrated in vacuo. The residue was dissolved in diethylether and washed with saturated NaHCO3 aqueous solution, brine, dried over MgSO4, and concentrated in vacuo. The compound was used for next reaction without purification.

1. temperaturethe mixture was heated
2. temperatureat reflux temperature for 8 hours
3. concentrationconcentrated in vacuo
4. dissolutionThe residue was dissolved in diethylether
5. washwashed with saturated NaHCO3 aqueous solution, brine
6. dry with materialdried over MgSO4
7. concentrationconcentrated in vacuo
8. customThe compound was used for next reaction without purification