反应详情

(RS) 3-{5-[2-(3-hydroxy-4-nitrophenyl)-acetylamino]-pyridin-2-yl}-butanoic acid (2.1 g, Reference Example 26) in methanol (80 mL) was treated with concentrated sulphuric acid (0.5 mL). The mixture was heated at reflux temperature for 24 hours, then cooled, then concentrated to low volume and then diluted with ethyl acetate. This solution was washed with 5% aqueous sodium bicarbonate, then with water, then dried over magnesium sulphate and then evaporated to give the title compound (2.0 g) as an oil.

1. temperatureThe mixture was heated
2. temperatureat reflux temperature for 24 hours
3. temperaturecooled
4. concentrationconcentrated to low volume
5. additiondiluted with ethyl acetate
6. washThis solution was washed with 5% aqueous sodium bicarbonate
7. dry with materialwith water, then dried over magnesium sulphate
8. customevaporated