Methanol → (RS) methyl 3-{5-[2-(3-hydroxy-4-nitrophenyl)-acetylamino]-pyridin-2-yl}-butanoate

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Reaction Steps

(RS) 3-{5-[2-(3-hydroxy-4-nitrophenyl)-acetylamino]-pyridin-2-yl}-butanoic acid (2.1 g, Reference Example 26) in methanol (80 mL) was treated with concentrated sulphuric acid (0.5 mL). The mixture was heated at reflux temperature for 24 hours, then cooled, then concentrated to low volume and then diluted with ethyl acetate. This solution was washed with 5% aqueous sodium bicarbonate, then with water, then dried over magnesium sulphate and then evaporated to give the title compound (2.0 g) as an oil.

Provenance & Evidence