Water → 1-(4-Bromo-2-methoxyphenyl)ethan-1-one

HRID 497229Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 497229
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[C:4]([OH:11])[CH:3]=1.[C:12](=O)([O-])[O-].[K+].[K+].CI.O>CN(C=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[C:4]([O:11][CH3:12])[CH:3]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 107274031-(4-Bromo-2-hydroxyphenyl)ethan-1-one

Produkt 1

HCID 112184481-(4-Bromo-2-methoxyphenyl)ethan-1-oneAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a stirred solution of 1-(4-bromo-2-hydroxyphenyl)-1-ethanone (28.8 g, 134 mmol), potassium carbonate (48.6 g, 352 mmol) in DMF (63 ml) was added methyl iodide (25 g, 0.176 mmol), and the mixture was stirred for 20 hours. The mixture was poured into water. The whole was extracted with diethylether. The organic layer was washed with brine, dried over MgSO4, and concentrated in vacuo. The residue was used for next reaction without purification. (31.5 g, 99% yield).

Aufarbeitung

  1. extractionThe whole was extracted with diethylether
  2. washThe organic layer was washed with brine
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated in vacuo
  5. customThe residue was used for next reaction without purification

Quellen und Nachweise

ORD-Eintrag
ord-ec5c06705f404cd88c46ee609d5d8cbb
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06949536B2

Notizen zur Reaktion

Wird geladen…