HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Amino-2-fluorobenzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | N-(3-fluoro-4-sulfamoylphenyl)acetamide | HCID 17812095 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Amino-2-fluorobenzenesulfonamide | HCID 22316898 | 63.5% |
Reaction Steps
A mixture of 4-acetamido-2-fluorobenzenesulfonamide (11.15 g, 48 mmol) and sodium hydroxide (11.5 g, 480 mmol) in water (80 mL) was heated at reflux temperature for 3 hours. The mixture was made neutral by addition of 2N—HCl solution, and resulting suspension was filtered to give the subtitle compound (5.8 g, 63.5% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06949536B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-a20b46dd49e34c2387f77c7f1fe52741 |
| Source note | uspto-grants-2005_09 |