3-Fluoro-4-sulfamoylphenylhydrazine hydrochloride → 4-[5-[3-Chloro-4-(2-furyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-fluorobenzenesulfonamide

HRID 497241Notes

Reaction equation

HRID 497241 reaction equation
Cl.[F:2][C:3]1[CH:4]=[C:5]([NH:13][NH2:14])[CH:6]=[CH:7][C:8]=1[S:9](=[O:12])(=[O:11])[NH2:10].[F:15][C:16]([F:35])([F:34])[C:17](=O)[CH2:18][C:19]([C:21]1[CH:26]=[CH:25][C:24]([C:27]2[O:28][CH:29]=[CH:30][CH:31]=2)=[C:23]([Cl:32])[CH:22]=1)=O>>[Cl:32][C:23]1[CH:22]=[C:21]([C:19]2[N:13]([C:5]3[CH:6]=[CH:7][C:8]([S:9]([NH2:10])(=[O:11])=[O:12])=[C:3]([F:2])[CH:4]=3)[N:14]=[C:17]([C:16]([F:35])([F:15])[F:34])[CH:18]=2)[CH:26]=[CH:25][C:24]=1[C:27]1[O:28][CH:29]=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 223166693-Fluoro-4-sulfamoylphenylhydrazine hydrochlorideHCID 223167001-[3-Chloro-4-(2-furyl)phenyl]-4,4,4-trifluoro-1,3-butanedione

Product 1

HCID 223167104-[5-[3-Chloro-4-(2-furyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-fluorobenzenesulfonamide

Procedure

The title compound was prepared according to the procedure of Example 60 using 3-fluoro-4-sulfamoylphenylhydrazine hydrochloride instead of 3-fluoro-4-(methylsulfonyl)phenylhydrazine hydrochloride and 4,4,4-trifluoro-1-[3-chloro-4-(2-furyl)phenyl]butane-1,3-dione instead of 4,4,4-trifluoro-1-[4-(2-furyl)phenyl]butane-1,3-dione in step 2.

Sources & evidence

ORD record
ord-b01d2354227d481c84abc108ad8674c6
Source dataset
uspto-grants-2005_09
Patent number
US06949536B2

Reaction notes

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