反应详情

A mixture of 3-(4-bromophenyl)-4-(3-fluoro-4-methylthiophenyl)-5-methyl-4,5-dihydro-5-isoxazolol (630 mg, 1.59 mmol) and p-toluenesulfonic acid monohydrate (274 mg, 1.59 mmol) in methanol (10 ml) was refluxed for 2 h. The mixture was evaporated, dissolved in ethyl acetate (100 ml), washed with saturated sodium bicarbonate (50 ml×2), and dried over anhydrous sodium sulfate. Removal of solvent gave 583 mg (97%) of the title compound as a pale yellow oil.

1. temperaturewas refluxed for 2 h
2. customThe mixture was evaporated
3. dissolutiondissolved in ethyl acetate (100 ml)
4. washwashed with saturated sodium bicarbonate (50 ml×2)
5. dry with materialdried over anhydrous sodium sulfate
6. customRemoval of solvent