3-Fluorobenzyl bromide → 1-(4-Bromo-3-methylphenyl)-2-(3-fluorophenyl)ethanone

HRID 497292Notes

Reaction equation

HRID 497292 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5]Br.[Br:10][C:11]1[CH:19]=[CH:18][C:14]([C:15](Cl)=[O:16])=[CH:13][C:12]=1[CH3:20]>>[Br:10][C:11]1[CH:19]=[CH:18][C:14]([C:15](=[O:16])[CH2:5][C:4]2[CH:7]=[CH:8][CH:9]=[C:2]([F:1])[CH:3]=2)=[CH:13][C:12]=1[CH3:20]

Participants

3

Reactant 2

HCID 680073-Fluorobenzyl bromideHCID 70215344-Bromo-3-methylbenzoyl chloride

Product 1

HCID 179234171-(4-Bromo-3-methylphenyl)-2-(3-fluorophenyl)ethanone

Procedure

The title compound was prepared according to the procedure of step 3 in the Example 169 using 3-fluorobenzyl bromide and 4-bromo-3-methylbenzoyl chloride (Cignarella; G.; Curzu, M. M.; Grella, G.; Loriga, M.; Anania, V.; Desole, M. S.; J. Farmaco. Ed. Sci., 1983, 38, 187-198.).

Sources & evidence

ORD record
ord-3d9fe5bbbab947a284e575064c4ecd79
Source dataset
uspto-grants-2005_09
Patent number
US06949536B2

Reaction notes

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