Triethylamine → HCID 22318908, compound

HRID 497313Notes

Reaction equation

HRID 497313 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][NH2:7].[C:13]([C:15]1[CH:16]=[C:17]([NH:21][C:22](=[O:34])[NH:23][C:24]2[CH:29]=[CH:28][C:27]([S:30](Cl)(=[O:32])=[O:31])=[CH:26][CH:25]=2)[CH:18]=[CH:19][CH:20]=1)#[N:14].C(N(CC)CC)C>C(#N)C>[C:13]([C:15]1[CH:16]=[C:17]([NH:21][C:22](=[O:34])[NH:23][C:24]2[CH:29]=[CH:28][C:27]([S:30]([NH:7][CH2:6][C:5]3[CH:8]=[CH:9][CH:10]=[C:3]([C:2]([F:11])([F:12])[F:1])[CH:4]=3)(=[O:31])=[O:32])=[CH:26][CH:25]=2)[CH:18]=[CH:19][CH:20]=1)#[N:14]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 759623-(Trifluoromethyl)benzylamineHCID 22318884HCID 22318884, compound

Product 1

HCID 22318908HCID 22318908, compoundYield 97.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

3-Trifluoromethylbenzylamine (0.52 g, 1 eq.) was added to a solution of 4-[3-(3-cyanophenyl)-ureido]-benzenesulfonyl chloride (1 g, 1 eq.) and triethylamine (1.05 ml, 1.6 eq.) in acetonitrile (10 ml) under inert atmosphere. The mixture was stirred for 3 d, concentrated in vacuo and water was added. The resulting precipitate was filtered off and dried in vacuo to yield 1.37 g (97%) of 4-[3-(3-cyanophenyl)-ureido]-N-(3-trifluoromethylbenzyl)-benzenesulfonamide.

Workup

  1. concentrationconcentrated in vacuo and water
  2. additionwas added
  3. filtrationThe resulting precipitate was filtered off
  4. customdried in vacuo

Sources & evidence

ORD record
ord-0aa29bbac2e844cba489cdd182ea07cf
Source dataset
uspto-grants-2005_09
Patent number
US06949567B2

Reaction notes

Loading…