Maleic Acid → HCID 86589741, compound

HRID 497319Notes

Reaction equation

HRID 497319 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([N:31]2[CH2:36][CH2:35][N:34]([CH3:37])[CH2:33][CH2:32]2)[CH2:10][N:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][CH2:20][C:21]3[C:30]4[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=4)[CH:24]=[CH:23][CH:22]=3)[CH2:13][CH2:12]2)=[CH:5][CH:4]=1.[C:38]([OH:45])(=[O:44])/[CH:39]=[CH:40]\[C:41]([OH:43])=[O:42]>C(O)C>[C:38]([OH:45])(=[O:44])/[CH:39]=[CH:40]\[C:41]([OH:43])=[O:42].[C:38]([OH:45])(=[O:44])/[CH:39]=[CH:40]\[C:41]([OH:43])=[O:42].[C:38]([OH:45])(=[O:44])/[CH:39]=[CH:40]\[C:41]([OH:43])=[O:42].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([N:31]2[CH2:36][CH2:35][N:34]([CH3:37])[CH2:33][CH2:32]2)[CH2:10][N:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][CH2:20][C:21]3[C:30]4[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=4)[CH:24]=[CH:23][CH:22]=3)[CH2:13][CH2:12]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 444266Maleic AcidHCID 10117829HCID 10117829, compound

Product 1

HCID 86589741HCID 86589741, compoundYield 90.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

0.94 g of 1-[2-(4-Methoxyphenyl)-2-(4-methylpiperazino)ethyl]-4-(4-naphthalen-1-yl-butyl)piperazine was dissolved in 5.0 ml of ethanol, 5.0 ml of an ethanol solution of 0.56 g of maleic acid was added, followed by being allowed to stand for 2 hours. The precipitated crystals were collected by filtration and washed with ethanol to give 1.24 g of 1-[2-(4-methoxyphenyl)-2-(4-methylpiperazino)ethyl]-4-(4-naphthalen-1-yl-butyl)piperazine trimaleate as crystals.

Workup

  1. filtrationThe precipitated crystals were collected by filtration
  2. washwashed with ethanol

Sources & evidence

ORD record
ord-7c03673d8b334109b822427eb952b587
Source dataset
uspto-grants-2005_09
Patent number
US06949552B2

Reaction notes

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