Maleic Acid → HCID 86589744, compound

HRID 497333Notes

Reaction equation

HRID 497333 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([N:34]2[CH2:39][CH2:38][N:37]([CH:40]([CH3:42])[CH3:41])[CH2:36][CH2:35]2)[CH2:9][N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][C:20]3[C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH:23]=[CH:22][C:21]=3[O:30][CH:31]([CH3:33])[CH3:32])[CH2:12][CH2:11]2)=[CH:4][CH:3]=1.[C:43]([OH:50])(=[O:49])/[CH:44]=[CH:45]\[C:46]([OH:48])=[O:47]>C(O)C>[C:43]([OH:50])(=[O:49])/[CH:44]=[CH:45]\[C:46]([OH:48])=[O:47].[C:43]([OH:50])(=[O:49])/[CH:44]=[CH:45]\[C:46]([OH:48])=[O:47].[C:43]([OH:50])(=[O:49])/[CH:44]=[CH:45]\[C:46]([OH:48])=[O:47].[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([N:34]2[CH2:39][CH2:38][N:37]([CH:40]([CH3:42])[CH3:41])[CH2:36][CH2:35]2)[CH2:9][N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][C:20]3[C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH:23]=[CH:22][C:21]=3[O:30][CH:31]([CH3:33])[CH3:32])[CH2:12][CH2:11]2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 444266Maleic AcidHCID 22318636HCID 22318636, compound

Product 1

HCID 86589744HCID 86589744, compoundYield 62.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

0.03 g of 1-[2-(4-Fluorophenyl)-2-(4-isopropylpiperazino)ethyl]-4-[4-(2-isopropoxy-naphthalen-1-yl)butyl]piperazine was dissolved in 2.0 ml of ethanol, and 2.0 ml of an ethanol solution of 0.02 g of maleic acid was added, followed by allowing to stand for 2 hours. The precipitated crystals were collected by filtration and washed with ethanol to give 0.03 g of 1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazino)ethyl]-4-[4-(2-isopropoxynaphthalen-1-yl)butyl]piperazine trimaleate as crystals.

Workup

  1. filtrationThe precipitated crystals were collected by filtration
  2. washwashed with ethanol

Sources & evidence

ORD record
ord-e8c720050ab3455d9d0de4236afee5be
Source dataset
uspto-grants-2005_09
Patent number
US06949552B2

Reaction notes

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