反应详情

Trifluoroacetic acid (60 mL) was charged into a flask, cooled in an ice/water bath, and 2-aminoindane hydrochloride (10.08 g) was added cautiously, followed by H2SO4 (6.0 mL) and HNO3 (3.0 mL). The ice bath was removed, and the mixture was allowed to warm to room temperature and stir for 2 hours. The mixture was then placed in an ice water bath for the slow addition of diethyl ether (300 mL) over 35 minutes. The mixture was stirred at room temperature overnight, then the solids were filtered and dried in vacuo to give 15.43 g of 2-amino-5-nitro-indane sulfate.

1. temperaturecooled in an ice/water bath
2. customThe ice bath was removed
3. additionThe mixture was then placed in an ice water bath for the slow addition of diethyl ether (300 mL) over 35 minutes
4. stirringThe mixture was stirred at room temperature overnight
5. filtrationthe solids were filtered
6. customdried in vacuo