反应详情

In a dry flask (3R,4R)-3-[(R)-1-phenyl-ethylamino]-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (31.32 g, 83.0 mmol) was dissolved in ethanol (400 mL). Potassium carbonate (68.72 g) was added and the mixture was refluxed for 6 hours. The reaction mixture was cooled, filtered through a bed of celite, and concentrated in vacuo to give a crude oil. Purification by flash column chromatography (20-50% ethyl acetate/hexanes) provided a colorless oil (4.59 g, 15%). Unepimerized ester was also isolated (23.49 g, 75%).

1. temperaturethe mixture was refluxed for 6 hours
2. temperatureThe reaction mixture was cooled
3. filtrationfiltered through a bed of celite
4. concentrationconcentrated in vacuo
5. customto give a crude oil
6. customPurification by flash column chromatography (20-50% ethyl acetate/hexanes)