3,5-Difluorophenol → 2-(3,5-Difluoro-phenoxy)-5-fluoro-nicotinic Acid Ethyl Ester

HRID 497530Notes

Reaction equation

HRID 497530 reaction equation
Cl[C:2]1[N:12]=[CH:11][C:10]([F:13])=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[F:14][C:15]1[CH:16]=[C:17]([OH:22])[CH:18]=[C:19]([F:21])[CH:20]=1>>[CH2:7]([O:6][C:4](=[O:5])[C:3]1[CH:9]=[C:10]([F:13])[CH:11]=[N:12][C:2]=1[O:22][C:17]1[CH:16]=[C:15]([F:14])[CH:20]=[C:19]([F:21])[CH:18]=1)[CH3:8]

Participants

3

Reactant 2

HCID 759283,5-DifluorophenolHCID 11390082Ethyl 2-chloro-5-fluoronicotinate

Product 1

HCID 208726372-(3,5-Difluoro-phenoxy)-5-fluoro-nicotinic Acid Ethyl EsterYield 23%

Procedure

The title compound was prepared from ethyl 2-chloro-5-fluoronicotinate and 3,5-difluorophenol in 23% yield following the procedure described in preparation 72.

Workup

  1. customdescribed in preparation 72

Sources & evidence

ORD record
ord-36d7ad892c0c4fd4ae53a73d64519e75
Source dataset
uspto-grants-2005_09
Patent number
US06949573B2

Reaction notes

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