Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 497530Generated: October 30, 2026

3,5-Difluorophenol → 2-(3,5-Difluoro-phenoxy)-5-fluoro-nicotinic Acid Ethyl Ester

https://huagongshe.com/reaction/497530

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-DifluorophenolHCID 75928—
ReactantEthyl 2-chloro-5-fluoronicotinateHCID 11390082—
Product2-(3,5-Difluoro-phenoxy)-5-fluoro-nicotinic Acid Ethyl EsterHCID 2087263723%

Reaction Steps

The title compound was prepared from ethyl 2-chloro-5-fluoronicotinate and 3,5-difluorophenol in 23% yield following the procedure described in preparation 72.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06949573B2
Source datasetuspto-grants-2005_09
ORD IDord-36d7ad892c0c4fd4ae53a73d64519e75
Source noteuspto-grants-2005_09