反应详情

930 mg of 3-benzyloxyphenylboronic acid, 1.24 g of caesium fluoride, 31.5 mg of 2-dicyclohexylphosphino-2′-(N,N-dimethylamino)diphenyl and 13.5 mg of palladium acetate are successively added to 1 g of N-[6-chloro-1-[[2-(trimethylsilyl)ethoxy)methyl]-1H-indazol-3-yl)butanamide, prepared in Example 25, and the mixture is refluxed for 18 hours. The reaction medium is filtered through a sinter funnel packed with Celite and 75 cm3 of ethyl acetate are added to the filtrate. The organic phase is washed with 25 cm3 of saturated sodium chloride solution, separated out after settling of the phases has taken place, dried over magnesium sulphate, filtered and concentrated to dryness under reduced pressure (2 kPa; 50° C.). The crude product obtained is purified by chromatography under an argon pressure of 50 kPa, on a column of silica gel (particle size 40-60 μm; diameter 2.5 cm), eluting with a cyclohexane/ethyl acetate gradient (90/10 to 75/25 by volume). The fractions containing the expected product are combined and evaporated under reduced pressure (2 kPa; 50° C.); 1.1 g of N-[6-[3-(phenylmethoxy)phenyl]-1-[[2-(trimethylsilyl)ethoxy)methyl]-1H-indazol-3-yl]butanamide are obtained in the form of an oil in a purity of 80%.

1. customprepared in Example 25
2. temperaturethe mixture is refluxed for 18 hours
3. filtrationThe reaction medium is filtered through a sinter funnel
4. additionare added to the filtrate
5. washThe organic phase is washed with 25 cm3 of saturated sodium chloride solution
6. customseparated out
7. dry with materialdried over magnesium sulphate
8. filtrationfiltered
9. concentrationconcentrated to dryness under reduced pressure (2 kPa; 50° C.)
10. customThe crude product obtained
11. customis purified by chromatography under an argon pressure of 50 kPa
12. washon a column of silica gel (particle size 40-60 μm; diameter 2.5 cm), eluting with a cyclohexane/ethyl acetate gradient (90/10 to 75/25 by volume)
13. additionThe fractions containing the expected product
14. customevaporated under reduced pressure (2 kPa; 50° C.)