HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Acetyl-4-aminopiperidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl (1-acetylpiperidin-4-yl)carbamate | HCID 22741830 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-Acetyl-4-aminopiperidine hydrochloride | HCID 17221642 | — |
Reaction Steps
To a solution of O-tert-butyl N-(1-acetylpiperidin-4-yl)carbamate (2.42 g) in dichloromethane (24 ml) was added 4N hydrogen chloride in dioxane (24 ml). The solvents were removed under reduced pressure. After rinse with diisopropyl ether, 1-acetyl-4-aminopiperidine hydrochloride (2.02 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710043B1 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-cc6b9275b92045789984f54272bb62b9 |
| Source note | uspto-grants-2004_03 |