Hydrochloric Acid → 1-Acetyl-4-aminopiperidine hydrochloride

HRID 49770Notes

Reaction equation

HRID 49770 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([NH:10]C(=O)OC(C)(C)C)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[ClH:18]>ClCCl.O1CCOCC1>[ClH:18].[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([NH2:10])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22741830tert-Butyl (1-acetylpiperidin-4-yl)carbamate

Product 1

HCID 172216421-Acetyl-4-aminopiperidine hydrochloride

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of O-tert-butyl N-(1-acetylpiperidin-4-yl)carbamate (2.42 g) in dichloromethane (24 ml) was added 4N hydrogen chloride in dioxane (24 ml). The solvents were removed under reduced pressure. After rinse with diisopropyl ether, 1-acetyl-4-aminopiperidine hydrochloride (2.02 g) was obtained.

Workup

  1. customThe solvents were removed under reduced pressure
  2. washAfter rinse with diisopropyl ether

Sources & evidence

ORD record
ord-cc6b9275b92045789984f54272bb62b9
Source dataset
uspto-grants-2004_03
Patent number
US06710043B1

Reaction notes

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