HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-Acetyl-1-piperazinesulfonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | 1-Acetylpiperazine | HCID 83795 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 4-Acetyl-1-piperazinesulfonyl chloride | HCID 22741825 | — |
Reaction Steps
A solution of sulfuryl chloride (3.55 ml) in chloroform (45 ml) was added a solution of 1-acetylpiperazine (5.66 mg) and triethylamine (6.16 ml) in chloroform (15 ml) dropwise under cooling on an ice-water bath. After stirring for 6 hours, a precipitate was collected by filtration. After drying over sodium hydroxide, 1-acetylpiperazine-4-sulfonyl chloride (2.43 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710043B1 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-92e5ed878f5a4e61a8b0ab794492acae |
| Source note | uspto-grants-2004_03 |