Triethylamine → 4-Acetyl-1-piperazinesulfonyl chloride

HRID 49772Notes

Reaction equation

HRID 49772 reaction equation
[S:1]([Cl:5])(Cl)(=[O:3])=[O:2].[C:6]([N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1)(=[O:8])[CH3:7].C(N(CC)CC)C>C(Cl)(Cl)Cl>[C:6]([N:9]1[CH2:14][CH2:13][N:12]([S:1]([Cl:5])(=[O:3])=[O:2])[CH2:11][CH2:10]1)(=[O:8])[CH3:7]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 24648Sulfuryl chlorideHCID 837951-Acetylpiperazine

Product 1

HCID 227418254-Acetyl-1-piperazinesulfonyl chloride

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

A solution of sulfuryl chloride (3.55 ml) in chloroform (45 ml) was added a solution of 1-acetylpiperazine (5.66 mg) and triethylamine (6.16 ml) in chloroform (15 ml) dropwise under cooling on an ice-water bath. After stirring for 6 hours, a precipitate was collected by filtration. After drying over sodium hydroxide, 1-acetylpiperazine-4-sulfonyl chloride (2.43 g) was obtained.

Workup

  1. temperatureunder cooling on an ice-water bath
  2. filtrationa precipitate was collected by filtration
  3. dry with materialAfter drying over sodium hydroxide

Sources & evidence

ORD record
ord-92e5ed878f5a4e61a8b0ab794492acae
Source dataset
uspto-grants-2004_03
Patent number
US06710043B1

Reaction notes

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