反应详情

1-Azabicyclo[2.2.2]octan-3-one (3.86 g) was heated at reflux with 2-chlorobenzaldehyde (8.33 ml), potassium hydroxide (0.4 g) and methanol (60 ml) under nitrogen for 2.5 hours. The volatiles were removed in vacuo and the residue washed with sodium hydrogen carbonate. This was extracted (×4) with dichloromethane. The organic layer was washed with water and dried (MgSO4). The dichloromethane was removed in vacuo and the residue recrystallised from methanol-dichloromethane, to afford the title compound as yellow crystals:

1. customThe volatiles were removed in vacuo
2. washthe residue washed with sodium hydrogen carbonate
3. extractionThis was extracted (×4) with dichloromethane
4. washThe organic layer was washed with water
5. dry with materialdried (MgSO4)
6. customThe dichloromethane was removed in vacuo
7. customthe residue recrystallised from methanol-dichloromethane