反应详情

2 ml of a dimethylformamide solution containing 0.07 g of 1-(2-pyridyl)-5-(2-pyridyl)-1,2-dihydropyridin-2-one was incorporated with 0.07 g of N-bromosuccinic acid imide, under stirring and ice-cooling. After stirring the mixture at room temperature for 2 hours, it was diluted with water and extracted with ethyl acetate. The organic layer was washed with water and brine, and then dried over magnesium sulfate. The solvent was evaporated, and the residue was purified by silica gel chromatography (ethyl acetate/hexane=3:1), to give 0.05 g of the title compound as a pale brown powder.

1. temperatureice-cooling
2. stirringAfter stirring the mixture at room temperature for 2 hours
3. extractionextracted with ethyl acetate
4. washThe organic layer was washed with water and brine
5. dry with materialdried over magnesium sulfate
6. customThe solvent was evaporated
7. customthe residue was purified by silica gel chromatography (ethyl acetate/hexane=3:1)