反应详情

To a suspension of 1-acetyl-4-aminopiperidine hydrochloride (536 mg) in dichloromethane (5 ml) were added 4-fluorophenyl isocyanate (375 μl) and diisopropylethylamine (575 μl ) at ambient temperature. After stirring for 3 hours, the reaction mixture was diluted with dichloromethane. An organic phase was separated and an aqueous phase was extracted with dichloromethane. A combined organic phase was dried over magnesium sulfate and the solvents were removed under reduced pressure. After crystallization from diisopropyl ether and n-hexane, N-(1-acetylpiperidin-4-yl)-N′-(4-fluorophenyl)urea (448 mg) was obtained.

1. customAn organic phase was separated
2. extractionan aqueous phase was extracted with dichloromethane
3. dry with materialA combined organic phase was dried over magnesium sulfate
4. customthe solvents were removed under reduced pressure
5. customAfter crystallization from diisopropyl ether and n-hexane