反应详情

温度

120 °C

A mixture of diethyl ethoxymethylenemalonate (32.5 g, 0.15 mol) and 3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-amine (23.8 g, 0.137 mol) was heated under reflux at 120° C. for 1 hour. After the mixture was allowed to cool to room temperature, the reaction solvent was evaporated under reduced pressure. The crude crystals thus obtained were filtered and washed with diethylether to give the title compound (45 g, 96% yield).

1. temperaturewas heated
2. temperatureto cool to room temperature
3. customthe reaction solvent was evaporated under reduced pressure
4. customThe crude crystals thus obtained
5. filtrationwere filtered
6. washwashed with diethylether